MOTS-C is a short bioactive peptide encoded by mitochondrial DNA and classified as a mitochondrial-derived peptide (MDP). It is widely studied in cellular metabolism and mitochondrial biology research due to its role in linking mitochondrial function with nuclear gene expression and systemic metabolic regulation.
In laboratory and preclinical research settings, MOTS-C is examined for its effects on glucose metabolism, insulin signaling pathways, fatty acid utilization, and cellular adaptation to metabolic stress. It has also been explored in studies focused on mitochondrial–nuclear communication, exercise-related signaling, and cellular resilience under energetic demand.
Research involving MOTS-C centers on mitochondrial signaling, metabolic flexibility, and cellular homeostasis mechanisms rather than therapeutic or clinical application.
